The tight junction can be modeled as a complex resistor array. (A) A simplified model of a three-strand tight junction barrier considered the strands in the vicinity of the recording electrode. A representative image of tight junction strands, as visualized by freeze–fracture electronmicroscopy, is shown. (B) Each resistor within the array representsmultiple parallel claudin-2 channels, and the overall array was simplified to two parallel resistors, RTJ and Rseal. (C) On the basis of analyses of tight junction patch clamp, each claudin-2 pore was defined by stable and unstable closed states (C1 and C2) and a single open state (O). 

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From  Weber, C. R. and J. R. Turner (2017). Dynamic modeling of the tight junction pore pathway. Ann N Y Acad Sci 1397:209-218.
Also see Weber, C. R., G. H. Liang, Y. Wang, S. Das, L. Shen, A. S. Yu, D. J. Nelson and J. R. Turner (2015). Claudin-2-dependent paracellular channels are dynamically gated. eLife 4:e09906.

 

Jerrold R. Turner, MD, PhD
Departments of Pathology
and Medicine (Gastroenterology)

Brigham and
Women's
Hospital

Harvard
Medical
School

Thorn 1428
20 Shattuck Street
Boston, MA 02115