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What's New

  • Congratulations Weiqi on your paper in CMGH! - More Info
  • Congratulations Sam on acceptance of your paper "Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability" in the Journal of Clinical Investigation
  • Congratulations Matt, Wangsun, and WeiTing on your "Editor's Choice" Selection in JBC - More Info
  • Congratulations Matt (on being selected for a JBC Author Profile)!!! - More Info
  • The ATLAS OF INTESTINAL TRANSPORT is LIVE! The Atlas contains images of intestinal tissues stained by H&E and immunofluorescence for specific transport proteins. These can be viewed using web-based virtual microscope software. Both human biopsies and mouse tissues are represented in health and selected disease states. A search tool allows images to be filtered based on species, stain, location, patient/mouse ID, and other parameters. - More Info

Our Research

In vivo wound repair

Intravital imaging of intestinal wound closure in a transgenic mouse expressing GFP-occludin (green) within intestinal epithelial cells under control of the villin promoter. Nuclei are shown in blue. The wound was created by laser photoablation. Note the expulsion of two damaged cells while the surrounding cells migrate beneath them.

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Our Goals 

Our interests are focused on how epithelia establish, maintain, and regulate barriers. This fundamental property is essential for survival of multicellular organisms and allows controlled interactions with the external environment and compartmentalization of distinct tissues. The structure that maintains these barriers and regulates flux between cells is the tight junction. The primary goal of our laboratory is to understand the biology of the tight junction.

We take a multidisciplinary approach that integrates cell and developmental biology, transport physiology, electrophysiology, structural biology, molecular biology, and mucosal immunology to define fundamentals of structure and function; understand mechanisms of regulation in vitro and in vivo models; determine the contributions of barrier dysfunction to gastrointestinal disease; understand the role of the epithelial barrier in regulating other mucosal processes, e.g. immune responses; and develop novel means to correct barrier function and restore health.

— Jerrold R. Turner MD, PhD

Jerrold R. Turner, MD, PhD
Professor of Pathology and Medicine

Brigham and
Women's
Hospital

Harvard
Medical
School

NRB 730
77 Avenue Louis Pasteur
Boston, MA 02115