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What's New

  • The ATLAS OF INTESTINAL TRANSPORT is LIVE!
  • The Atlas contains microscopic images of intestinal tissues stained by H&E and by immunofluorescence for specific transcellular and paracellular transport proteins. These can be viewed using a powerful virtual microscope. Both human biopsies and mouse tissues are represented in health and selected disease states. A search tool allows images to be filtered based on species, stain, location, patient/mouse ID, and other parameters. - More Info

Our Research

TNF-induced occludin endocytosis in vivo

Intravital imaging shows occludin endocytosis following TNF treatment. Transgenic mice imaged show EGFP-occludin (green) and mRFP1-ZO-1 (red) within jejunal epithelia. Occludin-containing vesicles form and move into the cytoplasm. ZO-1 is present at the tight junction, but is excluded from these vesicles. Nuclei are shown in blue. Images were collected from a single z plane from 85–140 min after TNF administration. J Cell Biol 2010;189:111-26

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Our Goals 

Our interests are focused on how epithelia establish, maintain, and regulate barriers. This fundamental property is essential for survival of multicellular organisms and allows controlled interactions with the external environment and compartmentalization of distinct tissues. The structure that maintains these barriers and regulates flux between cells is the tight junction. The primary goal of our laboratory is to understand the biology of the tight junction.

We take a multidisciplinary approach that integrates cell and developmental biology, transport physiology, electrophysiology, structural biology, molecular biology, and mucosal immunology to define fundamentals of structure and function; understand mechanisms of regulation in vitro and in vivo models; determine the contributions of barrier dysfunction to gastrointestinal disease; understand the role of the epithelial barrier in regulating other mucosal processes, e.g. immune responses; and develop novel means to correct barrier function and restore health.

— Jerrold R. Turner MD, PhD

Jerrold R. Turner, MD, PhD
Departments of Pathology
and Medicine (Gastroenterology)

Brigham and
Women's
Hospital

Harvard
Medical
School

NRB 730
77 Avenue Louis Pasteur
Boston, MA 02115