What's New

  • the Atlas of Intestinal Transport is now live! More images and scores coming soon - More Info
  • Holiday party pix 2017 - More Info
  • See us in The Scientist. "Image of the Day: Flushing the Gut" - More Info
  • TIght junctions are an essential component of innate immunity: Say yes to the leak! - More Info

Our Research

Occludin is co-internalized with caveolin-1

Live imaging of MDCK monolayers stably expressing caveolin-1-EGFP (green) and mRFP1-ZO-1 (red). Addition of latrunculin A, to inhibit ß-actin polymerization, causes co-internalization of caveolin-1 and occludin. The movie covers an interval of 3.5 minutes beginning approximately 5 minutes after latrunculin A addition. (Mol Biol Cell 2005;16:3919-36.)

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Our Goals 

Our interests are focused on how epithelia establish, maintain, and regulate barriers. This fundamental property is essential for survival of multicellular organisms and allows controlled interactions with the external environment and compartmentalization of distinct tissues. The structure that maintains these barriers and regulates flux between cells is the tight junction. The primary goal of our laboratory is to understand the biology of the tight junction.

We take a multidisciplinary approach that integrates cell and developmental biology, transport physiology, electrophysiology, structural biology, molecular biology, and mucosal immunology to define fundamentals of structure and function; understand mechanisms of regulation in vitro and in vivo models; determine the contributions of barrier dysfunction to gastrointestinal disease; understand the role of the epithelial barrier in regulating other mucosal processes, e.g. immune responses; and develop novel means to correct barrier function and restore health.

— Jerrold R. Turner MD, PhD

Jerrold R. Turner, MD, PhD
Departments of Pathology
and Medicine (Gastroenterology)

Brigham and
Women's
Hospital

Harvard
Medical
School

NRB 730
77 Avenue Louis Pasteur
Boston, MA 02115